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Table 5 Potential clinical application of ncRNAs function as ceRNAs in HCC

From: The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

ncRNA as ceRNA

Location

Clinical application

Description

Ref

circRNA_104075#

Serum

Diagnosis

AUC: 0.973, Se: 96.0%, Sp: 98.3%

[108]

BCYRN 1*

Serum

Diagnosis, prognosis, potential therapeutic target

Diagnosis: AUC: 0.7834, Se: 62.10%, Sp: 90.54%; Prognosis: overexpression associates with worse prognosis

[159, 160]

lncRNA-RP11‐513I15.6, miR‐1262, RAB11A

Serum

Diagnosis

AUC: NA, Se: 100%, Sp: 76.7%

[156]

OCT4-pg4^

Tissue

Prognosis, potential therapeutic target

Associates with prognosis

[10]

HOXD-AS1*

Tissue

Prognosis, potential therapeutic target

Associates with TNM stage and prognosis

[72]

SNHG6-003*

Tissue

Prognosis, potential therapeutic target

Associates with portal vein tumor thrombus, BCLC stage, distant metastasis and prognosis

[85]

AGAP2-AS1*

Tissue

Prognosis, potential therapeutic target

Associates with tumor size, histological grade, TNM stage, venous invasion and prognosis

[89]

CASC2*

Tissue

Prognosis, potential therapeutic target

Associates with venous infiltration, histological grade, TNM stage and prognosis

[98]

circRNA_104718#

Tissue

Prognosis, potential therapeutic target

Associates with vascular invasion and prognosis

[107]

circ_0000517#

Tissue

Prognosis, potential therapeutic target

Associated with tumor size, TNM stage, lymph node metastasis and prognosis

[127]

circNFATC3#

Tissue

Prognosis, potential therapeutic target

Associates with vascular invasion, histological grade and prognosis

[128]

MYCNOS, DLX6-AS1, LINC00221, CRNDE*

Tissue

Prognosis

Associates with prognosis

[161]

13 lncRNAs prognositc model

Tissue

Prognosis

Associates with prognosis

[162]

3 lncRNAs and 6mRNAs prognostic model

Tissue

Prognosis

Associates with prognosis

[163]

  1. ncRNA: non-coding RNA; ceRNA: competing endogenous RNA; HCC: hepatocellular carcinoma; AUC: Area under the curve; Se: Sensitivity; Sp: Specificity; NA: Not available; BCLC: Barcelona Clinic Liver Cancer; Ref: reference
  2. * Long non-coding RNA; #circular RNA; ^ pseudogene; ceRNA panel