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Table 5 Potential clinical application of ncRNAs function as ceRNAs in HCC

From: The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

ncRNA as ceRNA Location Clinical application Description Ref
circRNA_104075# Serum Diagnosis AUC: 0.973, Se: 96.0%, Sp: 98.3% [108]
BCYRN 1* Serum Diagnosis, prognosis, potential therapeutic target Diagnosis: AUC: 0.7834, Se: 62.10%, Sp: 90.54%; Prognosis: overexpression associates with worse prognosis [159, 160]
lncRNA-RP11‐513I15.6, miR‐1262, RAB11A Serum Diagnosis AUC: NA, Se: 100%, Sp: 76.7% [156]
OCT4-pg4^ Tissue Prognosis, potential therapeutic target Associates with prognosis [10]
HOXD-AS1* Tissue Prognosis, potential therapeutic target Associates with TNM stage and prognosis [72]
SNHG6-003* Tissue Prognosis, potential therapeutic target Associates with portal vein tumor thrombus, BCLC stage, distant metastasis and prognosis [85]
AGAP2-AS1* Tissue Prognosis, potential therapeutic target Associates with tumor size, histological grade, TNM stage, venous invasion and prognosis [89]
CASC2* Tissue Prognosis, potential therapeutic target Associates with venous infiltration, histological grade, TNM stage and prognosis [98]
circRNA_104718# Tissue Prognosis, potential therapeutic target Associates with vascular invasion and prognosis [107]
circ_0000517# Tissue Prognosis, potential therapeutic target Associated with tumor size, TNM stage, lymph node metastasis and prognosis [127]
circNFATC3# Tissue Prognosis, potential therapeutic target Associates with vascular invasion, histological grade and prognosis [128]
MYCNOS, DLX6-AS1, LINC00221, CRNDE* Tissue Prognosis Associates with prognosis [161]
13 lncRNAs prognositc model Tissue Prognosis Associates with prognosis [162]
3 lncRNAs and 6mRNAs prognostic model Tissue Prognosis Associates with prognosis [163]
  1. ncRNA: non-coding RNA; ceRNA: competing endogenous RNA; HCC: hepatocellular carcinoma; AUC: Area under the curve; Se: Sensitivity; Sp: Specificity; NA: Not available; BCLC: Barcelona Clinic Liver Cancer; Ref: reference
  2. * Long non-coding RNA; #circular RNA; ^ pseudogene; ceRNA panel