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Fig. 3 | Cancer Cell International

Fig. 3

From: Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis

Fig. 3

Hsa_circ_0026416 promotes CRC cell proliferation, migration and invasion in vitro. a, b Hsa_circ_0026416 was knocked down and overexpressed with transfection of an hsa_circ_0026416 overexpression plasmid and two different siRNAs in HCT-8 and SW480. cf Transwell assays indicated that knockdown of hsa_circ_0026416 inhibited migratory and invasive ability of HCT-8 and SW480 cells, while overexpression of hsa_circ_0026416 promoted migratory and invasive capacity. gj CCK-8 assays showing that knockdown of hsa_circ_0026416 inhibited proliferation of HCT-8 and SW480 cells, whereas overexpression of hsa_circ_0026416 enhanced proliferation capacity. kv Hsa_circ_0026416 had no effect on cell cycle distributions in HCT-8 and SW480 cells. Data are presented as means ± SD of three independent experiments. ns = no significant, *P < 0.05, **P < 0.01, *** or ****P < 0.001

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