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Table 1 Association between hsa_circ_0026416 expression and clinicopathological factors in CRC patients (n = 169)

From: Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis

Variables Patients Hsa_circ_0026416 expression χ2 P value
(n = 169) High (n = 86) Low (n = 83)
Gender     0.00 0.992
 Male 116 59 (68.6) 57 (68.67)   
 Female 53 27 (31.4) 26 (31.33)   
Age (years)     0.68 0.410
 ≤ 60 95 51 (59.3) 44 (53.01)   
 > 60 74 35 (40.7) 39 (46.99)   
Tumor location     3.45 0.063
 Colon 67 40 (46.51) 27 (32.53)   
 Rectum 102 46 (53.49) 56 (67.47)   
Tumor diameter (cm)     0.42 0.516
 ≤ 5 57 31 (36.05) 26 (31.33)   
 > 5 112 55 (63.95) 57 (68.67)   
Tumor differentiation     4.78 0.029*
 Poor 34 23 (26.74) 11 (13.25)   
 Well / Moderate 135 63 (73.26) 72 (86.75)   
pT stage     0.30 0.582
 T1–3 123 61 (70.93) 62 (74.7)   
 T4 46 25 (29.07) 21 (25.3)   
pN stage     1.06 0.304
 N0 93 44 (51.16) 49 (59.04)   
 N1–2 76 42 (48.84) 34 (40.96)   
Distant metastasis     14.73 0.000*
 M0 155 72 (83.72) 83 (100)   
 M1 14 14 (16.28) 0 (0)   
pTNM stage     8.07 0.004*
 I–II 73 28 (32.56) 45 (54.22)   
 III–IV 96 58 (67.44) 38 (45.78)   
Lymphovascular invasion     9.51 0.002*
 Yes 19 16 (18.6) 3 (3.61)   
 No 150 70 (81.4) 80 (96.39)   
Perineural invasion     8.10 0.004*
 Yes 8 8 (9.3) 0 (0)   
 No 161 78 (90.7) 83 (100)   
Postoperative recurrence or metastasis     0.01 0.908
 Yes 34 17 (19.77) 17 (20.48)   
 No 135 69 (80.23) 66 (79.52)   
  1. *Significant difference