Table 1 Association between hsa_circ_0026416 expression and clinicopathological factors in CRC patients (n = 169)
From: Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis
Variables | Patients | Hsa_circ_0026416 expression | χ2 | P value | |
|---|---|---|---|---|---|
(n = 169) | High (n = 86) | Low (n = 83) | |||
Gender | Â | Â | Â | 0.00 | 0.992 |
 Male | 116 | 59 (68.6) | 57 (68.67) |  |  |
 Female | 53 | 27 (31.4) | 26 (31.33) |  |  |
Age (years) | Â | Â | Â | 0.68 | 0.410 |
 ≤ 60 | 95 | 51 (59.3) | 44 (53.01) |  |  |
 > 60 | 74 | 35 (40.7) | 39 (46.99) |  |  |
Tumor location | Â | Â | Â | 3.45 | 0.063 |
 Colon | 67 | 40 (46.51) | 27 (32.53) |  |  |
 Rectum | 102 | 46 (53.49) | 56 (67.47) |  |  |
Tumor diameter (cm) | Â | Â | Â | 0.42 | 0.516 |
 ≤ 5 | 57 | 31 (36.05) | 26 (31.33) |  |  |
 > 5 | 112 | 55 (63.95) | 57 (68.67) |  |  |
Tumor differentiation | Â | Â | Â | 4.78 | 0.029* |
 Poor | 34 | 23 (26.74) | 11 (13.25) |  |  |
 Well / Moderate | 135 | 63 (73.26) | 72 (86.75) |  |  |
pT stage | Â | Â | Â | 0.30 | 0.582 |
 T1–3 | 123 | 61 (70.93) | 62 (74.7) |  |  |
 T4 | 46 | 25 (29.07) | 21 (25.3) |  |  |
pN stage | Â | Â | Â | 1.06 | 0.304 |
 N0 | 93 | 44 (51.16) | 49 (59.04) |  |  |
 N1–2 | 76 | 42 (48.84) | 34 (40.96) |  |  |
Distant metastasis | Â | Â | Â | 14.73 | 0.000* |
 M0 | 155 | 72 (83.72) | 83 (100) |  |  |
 M1 | 14 | 14 (16.28) | 0 (0) |  |  |
pTNM stage | Â | Â | Â | 8.07 | 0.004* |
 I–II | 73 | 28 (32.56) | 45 (54.22) |  |  |
 III–IV | 96 | 58 (67.44) | 38 (45.78) |  |  |
Lymphovascular invasion | Â | Â | Â | 9.51 | 0.002* |
 Yes | 19 | 16 (18.6) | 3 (3.61) |  |  |
 No | 150 | 70 (81.4) | 80 (96.39) |  |  |
Perineural invasion | Â | Â | Â | 8.10 | 0.004* |
 Yes | 8 | 8 (9.3) | 0 (0) |  |  |
 No | 161 | 78 (90.7) | 83 (100) |  |  |
Postoperative recurrence or metastasis | Â | Â | Â | 0.01 | 0.908 |
 Yes | 34 | 17 (19.77) | 17 (20.48) |  |  |
 No | 135 | 69 (80.23) | 66 (79.52) |  |  |