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Fig. 5 | Cancer Cell International

Fig. 5

From: MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation

Fig. 5

MiR-1307-5p targets TRAF3 to regulate the NF-κB/MAPK pathway. a, b Western blot was used to detect the difference of NF-κB pathway protein levels in each treatment group after transient transfection of H1299 and A549 lung adenocarcinoma cells. Overexpression of miR-1307-5p upregulated p-p65 protein expression level and inhibited miR-1307-5p downregulated p-p65 protein expression level. Compared with the control group, *P < 0.05 and **P < 0.01. c, d Western blot was used to detect the difference of MAPK pathway protein levels in the treatment groups after transient transfection of H1299 and A549 lung adenocarcinoma cells. Overexpression of miR-1307-5p activated the MAPK pathway and knockdown of miR-1307-5p inhibited the MAPK pathway. Compared with the control group, *P < 0.05 and **P < 0.01. Data are expressed as mean ± standard deviation. The experiment was repeated three times

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Cancer Cell International

ISSN: 1475-2867

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