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Fig. 3 | Cancer Cell International

Fig. 3

From: Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer

Fig. 3

PD enhanced the sensitivity of MDA-MB-231 cells to CDDP. a The cell viability of MDA-MB-231 cells after exposure to each treatment regimen was determined by CCK8 assay. b A colony formation assay and its quantification of MDA-MB-231 cells after each treatment regimen had been performed. c The IC50 of CDDP (drug concentration required to inhibit growth by 50%) was calculated in MDA-MB-231 cells treated with PD + CDDP, PD-CDDP or CDDP-PD. d Combination index (CI) obtained from dose–response analysis of the CDDP and PD treatments. The data, which were analysed with CompuSyn software, were used to measure whether the two drugs had a synergistic (CI < 1), additive (CI = 1) or antagonistic (CI > 1) effect

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Cancer Cell International

ISSN: 1475-2867

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