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Fig. 4 | Cancer Cell International

Fig. 4

From: Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer

Fig. 4

PD-CDDP treatment effectively delayed the proliferation of MDA-MB-231 xenografts in vivo. a Sample dosing schedule for PD and CDDP. b Randomly grouped nude mice bearing MDA-MB-231 tumours were treated with vehicle (PBS), PD (150 mg/kg), CDDP (5 mg/kg), or PD-CDDP treatment for three cycles. Tumour volume was determined every 3 days after the onset of treatment. c Harvested tumours were subsequently collected, and representative immunohistochemistry results show Ki-67 expression in MDA-MB-231 tumours. The percentage of Ki-67-positive tumour cells and their staining intensities were assessed by ImageJ

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