Fig. 7From: Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancera PD-CDDP treatment enhanced the antitumour effect of CDDP through the cyclin D1/RB/E2F axis. Western blot analysis was performed to assess cyclin D1, total RB, p-RB, E2F1, PARP/cleaved PARP, γH2AX and β-actin expression. b Proposed model for the mechanism of PD-CDDP treatmentBack to article page