Fig. 2

CTLA4 indicated a higher density of TILs in ccRCC tumor microenvironment, but an immunosuppressed phenotype. a CTLA4 is positively correlated with T cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation and Th17 cell differentiation. b CTLA4 is positively correlated with T cell activation and T cell differentiation. c Highly expressed CTLA4 has a higher Immune score, indicating that there are more TILs within the TME. d CTLA4 is positively correlated with infiltrating CD8+ T cells and Tregs. e, f Highly expressed CTLA4 is accompanied by a higher Immunosuppression score and higher expression of T cell exhaustion markers, indicating an immunosuppressed phenotype. TILs, tumor-infiltrating lymphocytes; TME, tumor microenvironment; Tregs, T regulatory cells