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Fig. 3 | Cancer Cell International

Fig. 3

From: Suppressive effects of plumbagin on the growth of human bladder cancer cells via PI3K/AKT/mTOR signaling pathways and EMT

Fig. 3

Cell cycle of BCa cells was arrested in G0/G1 phase by plumbagin treatment. a, b Representative FACS images of cell cycle with plumbagin treatment in T24 and UMUC3 cells, respectively, and quantitative analysis of cell cycle proportions showed a remarkable increase in G0/G1 phase cells; c, d The relative mRNA expression of MDM2, GADD, p53, CDK2, CDK4, p21 and CDK6 could be modulated when T24 and UMUC3 cells were treated with plumbagin at 0, 0.75, 1.5 μM; e The expression levels of CDK2, CDK4, CDK6, CCND1, CCNE1, CCNB1, p53, p27, p21 were determined by western blotting assay. GAPDH was as the internal control. **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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