LncRNA SNHG3, a potential oncogene in human cancers

Xu, Bin; Mei, Jie; Ji, Wei; Bian, Zheng; Jiao, Jiantong; Sun, Jun; Shao, Junfei

doi:10.1186/s12935-020-01608-x

Cancer Cell International

Table 1 Functional characterization of SNHG3 in various cancers

From: LncRNA SNHG3, a potential oncogene in human cancers

Cancer type	Expression	Role	Biological functions	Related genes	Refs.
Breast cancer	Up	Oncogenic	Promotes cell proliferation, migration and invasion	miR-384/HDGF	[31,32,33]
				miR-330-5p/PKM
				miR-326/ITGA5, Vav2/Rac1
Osteosarcoma	Up	Oncogenic	Promotes cell proliferation, migration, invasion and EMT	miR-151a-3p/RAB22A, miR-196a-5p/HOXC8	[25, 38]
Glioma	Up	Oncogenic	Promores cell proliferation, inhibits apoptosis, and regulates cell cycle	KLF2, p21, EZH2	[24]
Laryngeal cancer	UP	Oncogenic	Promotes cell migration, invasion and cell viability, glycolysis	miR-384/WEE1, MMP2, MMP9	[44, 45]
Laryngeal cancer	UP	Oncogenic		miR-340-5p/YAP1, Wnt/β-catenin	[44, 45]
Gastric cancer	Up	Oncogenic	Promotes cell proliferation, migration, invasion and cell viability	EZH2, MED18	[23]
Colorectal cancer	Up	Oncogenic	Promotes cell proliferation, migration, invasion and cell viability	miR-182-5p/c-Myc, miR-539/RUNX2	[53, 54]
Renal cell carcinoma	Up	Oncogenic	Promotes cell proliferation, cell viability, migration, invasion and EMT and inhibits cell apoptosis	miR-139-5p/TOP2A, CDK6, Bax, Bcl-2, N-cadherin, E-cadherin, Vimentin	[57]
Hepatocellular carcinomac	Up	Oncogenic	Promotes cell proliferation, apoptosis, migration, invasion, EMT and sorafenib resistance	miR-139-5p/BMI1, miR-326/SMAD3/ZEB1, miR-128/CD151/AKT/PI3K, N-cadherin, E-cadherin, Vimentin, Snail	[60,61,62,63]
Lung cancer	Up	Oncogenic	Promotes cell proliferation, migration and EMT, inhibits cell apoptosis and regulates cell cycle	TGF-β, IL-6/JAK2/STAT3	[66, 67]
Acute myeloid leukemia	Up	Oncogenic	Promotes cell proliferation and inhibits cell apoptosis	miR-758-3p/SRGN	[70, 71]
Epithelial ovarian cancer	Up	Oncogenic	Promotes cell proliferation, invasion and glycolysis	CyclinD1, CDK1, MMP9, MMP3, GSK3β/β-catenin, EIF4A3-mRNA	[26, 74]
Papillary thyroid carcinoma	Up	Oncogenic	Promotes cell proliferation, migration and invasion	miR-214-3p/PSMD10	[76]
Papillary thyroid carcinoma	Down	Tumor Suppressive	Promotes cell proliferation, migration and invasion	AKT/mTOR/ERK	[77]
Prostate cancer	UP	Oncogenic	Promotes cell proliferation, migration, invasion, EMT process and inhibits cell apoptosis	miR-577/SMURF1	[78]
Bladder cancer	Up	Oncogenic	Promotes cell proliferation, migration, invasion and EMT	miR-515-5p/GINS2	[79]
Oral squamous cell carcinoma	Up	Oncogenic	Promotes cell migration, invasion and proliferation	ELAVL1/NFYC, Wnt/β-catenin	[80]

EMT epithelial-mesenchymal transition, HDGF hepatoma-derived growth factor, PKM pyruvate kinase M1/M2, ITGA5 integrin α5, RAB22A Ras-related proteins 22a, HOXC8 homeobox c8, KLF2 kruppel like factor 2, p21 p21 protein, EZH2 Enhancer of zeste homolog 2, WEE1 wee1-like protein kinase, MMP2 matrix metalloproteinase-2, MMP9 matrix metalloproteinase-9, YAP1 yes-associated protein 1, MED18 mediator subunit18, RUNX2 runt-related transcription factor 2, TOP2A the expression of topoisomerase IIα, CDK6 cyclin-dependent kinase 6, N-cadherin neural-cadherin, E-cadherin epithelial-cadherin, BMI1 B lymphoma Mo-MLV insertion region 1, SMAD3 Sma and Mad Related Family 3, ZEB1 zinc finger E-box binding homeobox 1, PI3K phosphoinositide-3 kinase, TGF-β transforming growth factor-β, IL-6 the interleukin-6, JAK2 Janus kinase 2, STAT3 signal transducer and activator of transcription 3, SRGN serglycin, GSK3β glycogen synthase kinase 3 beta, EIF4A3 eukaryotic translation initiation factor 4A3, SMURF1 Smad Ubiquitin Regulatory Factor 1, GINS2 GINS complex subunit 2, PSMD10 proteasome 26S subunit non-ATPase 10, ELAVL1 ELAV like RNA-binding protein 1, NFYC nuclear transcription factor Y subunit gamma

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