Targeted nanobody complex enhanced photodynamic therapy for lung cancer by overcoming tumor microenvironment

Table 1 ALB/c mice injected with Nb@IC-NPs was sacrificed on the 1st and 7th day

	WBC(10⁹/L)	RBC(10¹²/L)	HGB(g/L)	HCT(%)	MCV(fL)	MCH(pg)
Reference range	5.64–14.85	8.16–11.69	124 –189	43 –67	50.8 –64.1	13 – 17.6
Healthy control	5.25 ± 1.12	10.36 ± 0.41	154.0 ± 5.6	49.0 ± 2.4	47.3 ± 0.6	14.7 ± 0.3
1D after treatment	6.08 ± 1.10	8.90 ± 2.57	158.2 ± 35.6	41.5 ± 12.9	46.1 ± 1.3	14.4 ± 0.6
7D after treatment	6.50 ± 1.65	10.8 ± 0.61	159.1 ± 8.5	50.2 ± 2.1	46.6 ± 0.8	14.6 ± 0.4

	MCHC(g/L)	PLT(10⁹/L)	ALT(U/L)	ALP(U/L)	AST(U/L)
Reference range	239 – 331	476 – 1611	40 – 170	108 – 367	67 –381
Healthy control	312.2 ± 2.5	914.7 ± 226	52.4 ± 10.5	159.4 ± 49.2	226.0 ± 14.4
1D after treatment	309.3 ± 9.8	821.4 ± 309	52.2 ± 14.2	163.5 ± 41.0	180.9 ± 15.2
7D after treatment	316.1 ± 4.2	1168 ± 257	65.6 ± 10.1	180.4 ± 47.4	177.5 ± 24.1

Healthy Mice without processing was used as control. Complete blood count: WBC White Blood Cells, RBC Red Blood Cells, HGB Hemoglobin, HCT Hematocrit, MCV Mean Corpuscular Volume, MCH Mean Corpuscular Hemoglobin, MCHC Mean Corpuscular Hemoglobin Concentration. Serum Biochemical Parameters: ALT lanine Transaminase, ALP Alkaline Phosphatase, AST Aspartate Aminotransferase

ISSN: 1475-2867