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Fig. 6 | Cancer Cell International

Fig. 6

From: Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1

Fig. 6

TXNRD1 was a target gene of miR-1305. a The binding sequence between TXNRD1 3′UTR and miR-1305 was predicted by TargetScan 7.0. b Luciferase reporter assay was used to observe the relationship between miR-1305 and TXNRD1. **P < 0.001, compared with miR-NC. miR-NC: miR-1305 negative control, WT: TXNRD1 wild type, Mut: TXNRD1 mutant type. c RNA pull-down assay was used to determine the relationship between miR-1305 and TXNRD1. **P < 0.001, compared with Bio-NC. Bio-NC: Bio-miR-1305 negative control. Bio-miR-1305: miR-1305 mimic-biotin. d RT-qPCR analysis showed that the expression of TXNRD1 was increased in ESCC tissues. e Pearson’s correlation analysis revealed that MiR-1305 had a negative relationship with TXNRD1. Each cellular experiment was independently repeated three times, and the data collected were displayed in the format of mean ± standard deviation (SD)

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