Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1

Table 1 Correlation between circ0120816 expression and clinical features of ESCC patients

Characteristics	Total = 36	Expression of circ0120816		P value^a
Characteristics	Total = 36	High (n = 20)	Low (n = 16)	P value^a
Age(years)				0.765
≤ 60	17 (47.2%)	9 (45.0%)	8 (50.0%)
> 60	19 (52.8%)	11 (55.0%)	8 (50.0%)
Gender				0.940
Female	16 (44.4%)	9 (45.0%)	7 (43.8%)
Male	20 (55.6%)	11 (55.0%)	9 (56.2%)
Tumor location in esophagus				0.491
Upper	8 (22.2%)	3 (15.0%)	5 (31.3%)
Middle	17 (47.2%)	10 (50.0%)	7 (43.7%)
Lower	11 (30.6%)	7 (35.0%)	4 (25.0%)
Pathological T stage				0.020^b
T1	10 (27.8%)	2 (15.0%)	8 (43.8%)
T2	16 (44.4%)	10 (45.0%)	6 (43.8%)
T3	10 (27.8%)	8 (40.0%)	2 (12.5%)
Lymph node metastasis
No	21 (58.3%)	7 (35.0%)	14 (87.5%)	0.001^b
Yes	15 (41.7%)	13 (65.0%)	2 (12.5%)
Differentiation				0.285
Well	7 (19.4%)	3 (25%)	4 (7.4%)
Moderately	20 (55.6%)	10 (55%)	10 (51.9%)
Poorly	9 (25.0%)	7 (20%)	2 (40.7%)

^aP value comparison between higher and lower circ0120816 expression (cut by the mean level) in ESCC tumor tissues; ^bP < 0.05

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