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Fig. 7 | Cancer Cell International

Fig. 7

From: LncRNA NEAT1 promotes proliferation, migration, invasion and epithelial-mesenchymal transition process in TGF-β2-stimulated lens epithelial cells through regulating the miR-486-5p/SMAD4 axis

Fig. 7

Effects of TGF-β2, NEAT1, miR-486-5p and SMAD4 on the activity of the TGF-β/SMAD signaling pathway. a WB analysis suggested that TGF-β2 could promote the protein levels of p-SMAD2 and p-SMAD3 (P < 0.0001) in SRA01/04 cells. b TGF-β2-stimulated SRA01/04 cells were transfected with si-NEAT1 or co-transfected with si-NEAT1 and anti-miR-486-5p or SMAD4. WB analysis showed that the inhibition effect of NEAT1 silencing on protein levels of p-SMAD2 and p-SMAD3 could be reversed by miR-486-5p inhibitor and SMAD4 overexpression (P < 0.0001). c The summary diagram of this study was shown. ****P < 0.0001

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Cancer Cell International

ISSN: 1475-2867

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