Fig. 1

miR-206 levels predict the response to platinum-based chemotherapy and survival in Chinese EOC patients. a Hierarchical clustering of miRNA microarray analysis between epithelial ovarian cancer (EOC) samples with complete response (CR) and incomplete response (IR) to platinum-based chemotherapy (n = 17) (P < 0.0001). b miR-206 expression in a verified cohort of EOC patients (n = 39) by qRT-PCR. miR-206 was significantly upregulated in the IR group (n = 19) vs. the CR group (n = 20) (P = 0.0033). c Receiver operating characteristic (ROC) curve of the cisplatin responders. A Mann–Whitney U test demonstrated that miR-206 expression distinguished IR patients from CR patients (P < 0.001). The area under the curve (AUC) is 0.829 (0.707–0.951). d Kaplan–Meier curves showing the overall survival of EOC patients stratified by expression levels of miR-206. The qRT-PCR data of miR-206 was separated into high and low expression groups by the median value. (n = 20 for CR and n = 19 for IR, P < 0.001). e Kaplan–Meier curves showing that the response to chemotherapy was related to patient prognosis