Table 1 Characteristics of studies included in the current study
Study (first author, year) | Country | Study design, Year of inclusion | Treatment | Definition of SV-UCB | Number of patients | Reported outcomes for comparison between-SV-UCB and C-UCB | Data on NAC/AC benefit for SV-UVB | Data used for the following meta-analysis |
|---|---|---|---|---|---|---|---|---|
Berg (2019) | United States and Puerto Rico | Retrospective, 2004–2015 | Radical cystectomy | Any component of sarcomatoid variant | SV-UCB: 388 C-UCB: 13,210 | AC, unadjusted OS | AC benefit on OS | AC, unadjusted OS, AC benefit on OS |
Robinson (2018) | United Kingdom | Retrospective, 1999–2015 | Radical cystectomy | Any component of sarcomatoid variant | SV-UCB: 12 C-UCB: 230 | pT stage, high grade, concomitant CIS, pN + , surgical margin + , unadjusted OS/CSS/PFS | NR | pT stage, high grade, concomitant CIS, pN + , surgical margin + , unadjusted OS/CSS/PFS |
Vetterlein (2017) | United States and Puerto Rico | Retrospective, 1998–2012 | Radical cystectomy | Any component of sarcomatoid variant | SV-UCB: 304 | NR | NAC benefit on OS | NAC benefit on OS |
Sui (2017) | United States | Retrospective, 2004–2013 | Radical cystectomy | Any component of sarcomatoid variant | SV-UCB: 220 | NR | NAC and AC benefit on OS | NAC and AC benefit on OS |
Moschini (2017) | Italy | Retrospective, 1990–2013 | Radical cystectomy | Sarcomatoid variant histology without any other variant histology | SV-UCB: 21 C-UCB: 729 | NAC, AC, pT stage, concomitant CIS, pN + , surgical margin + , adjusted OS/ CSS/PFS | NR | NAC, AC, pT stage, concomitant CIS, pN + , surgical margin + , adjusted OS/CSS/PFS |
Monn (2015) | United States | Retrospective, 2008–2013 | Radical cystectomy | Any component of sarcomatoid variant, regardless of overall percentage. In mixed variant histology, sarcomatoid variant with the highest percentage present | SV-UCB: 15 C-UCB: 462 | NAC, AC, pT stage, pN + , surgical margin + , adjusted OS | NR | NAC, AC, pT stage, pN + , surgical margin + , adjusted OS |
Wang (2011) | United States | Retrospective, 1997–2011 | Radical cystectomy, TURBT, etc | Any component of sarcomatoid variant | SV-UCB: 14 C-UCB: 319 | high grade | NR | high grade |
Wright (2007) | United States | Retrospective, 1988–2003 | Radical cystectomy, TURBT, etc | Any component of sarcomatoid variant | SV-UCB: 301 C-UCB: 46,515 | pT stage, unadjusted CSS, adjusted OS/CSS | NR | pT stage, unadjusted CSS, adjusted OS/CSS |