Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis

Huang, Runzhi; Zeng, Zhiwei; Yan, Penghui; Yin, Huabin; Zhu, Xiaolong; Hu, Peng; Zhuang, Juanwei; Li, Jiaju; Li, Siqi; Song, Dianwen; Meng, Tong; Huang, Zongqiang

doi:10.1186/s12935-020-01632-x

Cancer Cell International

Table 1 External Validation of Biomarkers in SARC via Multiple Online Database

From: Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis

	PAX5	LTB (anti-oncogene)	IL1A (anti-oncogene)	IL5RA (anti-oncogene)	IL7 (anti-oncogene)	LY9 (anti-oncogene)	SLAMF7 (anti-oncogene)	ICAM1 (anti-oncogene)
Oncomine	Expression: NA	Expression: Low	Expression: NA	Expression: High	Expression: NA	Expression: Low	Expression: Low	Expression: Low
UALCAN	Expression: NA Survival: P = 0.290	Expression: P < 0.001 Survival: P = 0.006	Expression: P < 0.001 Survival: P = 0.019	Expression: P = 0.781 Survival: P = 0.031	Expression: 0.471 Survival: P = 0.041	Expression: P < 0.001 Survival: P = 0.008	Expression: P < 0.001 Survival: P = 0.013	Expression: P = 0.521 Survival: P = 0.030
K-M Plotter	Survival: P = 0.084	Survival: P < 0.001	Survival: P = 0.003	Survival: P < 0.001	Survival: P = 0.010	Survival: P < 0.001	Survival: P = 0.006	Survival: P = 0.015
GEPIA	Survival: P = 0.380 Correlation: P < 0.001 R = 0.34	Survival: P = 0.004	Survival: P = 0.056 Correlation: P = 0.016 R = 0.15	Survival: P < 0.001 Correlation: P < 0.001 R = 0.41	Survival: P = 0.120 Correlation: P < 0.001 R = 0.50	Survival: P = 0.006 Correlation: P < 0.001 R = 0.81	Survival: P = 0.078 Correlation: P < 0.001 R = 0.79	Survival: P = 0.037 Correlation: P < 0.001 R = 0.56
LinkedOmics	Survival: P = 0.500 Correlation: P < 0.001 R = 0.31	Survival: P < 0.001	Survival: P = 0.015 Correlation: P = 0.008 R = 0.17	Survival: P = 0.030 Correlation: P < 0.001 R = 0.43	Survival: P = 0.022 Correlation: P < 0.001 R = 0.51	Survival: P = 0.001 Correlation: P < 0.001 R = 0.82	Survival: P = 0.008 Correlation: P < 0.001 R = 0.79	Survival: P = 0.035 Correlation: P < 0.001 R = 0.61
TISIDB	Survival: NA	Survival: P = 0.006	Survival: P = 0.019	Survival: NA	Survival: P = 0.021	Survival: P < 0.001	Survival: P = 0.006	Survival: P = 0.043
cBioportal	Correlation: P < 0.001 R = 0.31		Correlation: P = 0.009 R = 0.16	Correlation: P < 0.001 R = 0.43	Correlation: P < 0.001 R = 0.52	Correlation: P < 0.001 R = 0.83	Correlation: P < 0.001 R = 0.79	Correlation: P < 0.001 R = 0.60

PAX5: Paired Box 5; LTB: Lymphotoxin Beta; IL1A: Interleukin 1 Alpha; IL5RA: Interleukin 5 Receptor Subunit Alpha; IL7: Interleukin 7; LY9: Lymphocyte Antigen 9; SLAMF7: Signaling Lymphocytic Activation Molecule Family Member 7; ICAM1: Intercellular Adhesion Molecule 1

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ISSN: 1475-2867

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