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Fig. 5 | Cancer Cell International

Fig. 5

From: Histone methyltransferase SUV39H2 regulates LSD1-dependent CDH1 expression and promotes epithelial mesenchymal transition of osteosarcoma

Fig. 5

SUV39H2 facilitates the progression of OS through suppression of CDH1 expression in vivo. The BALB/c nude mice were injected with cells transduced with lentiviral plasmids containing oe-NC, oe-SUV39H2, oe-SUV39H2 + oe-NC or oe-SUV39H2 + oe-CDH1 (n = 8). a The representative images of transplanted tumors in nude mice. b Tumor volume of nude mice. c Tumor weight of nude mice. d SUV39H2, LSD1 and CDH1 expression normalized to GAPDH in tumor tissues detected using Western blot analysis. e The expression of VEGF in each group measured using immunohistochemistry. *p < 0.05 vs. mice injected with oe-NC-infected cells. #p < 0.05 vs. mice inoculated by cells transduced with oe-SUV39H2 + oe-NC. Measurement data are expressed as mean ± standard deviation derived from at least 3 independent experiments. The data comparison between multiple groups was performed using one-way ANOVA, followed with Tukey’s post hoc test. For data comparison among groups at different time points, repeated measures ANOVA was used

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