Table 1 General characteristics and quality assessment of the included studies

Boutsikou [20]

Docetaxel (100 mg/m²) + Carboplatin (5 mg/mL*min) + Bevacizumab (7.5 mg/kg)

56

63

80.4

73.2

0

0

Moderate

Docetaxel (100 mg/m²) + Carboplatin (5 mg/ mL*min)

61

65

85.2

83.6

0

0

Fukuda [21]

Bevacizumab (15 mg/kg) + pemetrexed (500 mg/m²)

20

78.5

55

75

0

0

Moderate

pemetrexed (500 mg/m²)

20

77.5

60

75

0

0

Galetta [22]

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab (15 mg/kg)

58

62

77.6

93.1

0

0

High

Pemetrexed (500 mg/m²) + Cisplatin (75 mg/m²)

60

60

70

95

0

0

Gronberg [23]

Gemcitabine (1,000 mg/m²) + Carboplatin (6 mg/ mL*min)

217

66

59.0

71.9

23.0

22.6

High

Pemetrexed (500 mg/m²) + Carboplatin (6 mg/ mL*min)

219

64

56.2

71.2

26.0

21.5

Han [24]

Paclitaxel (175 mg/m² on day 1) + Carboplatin (5 mg/ mL*min on day 1) + Endostar (7.5 mg/m²/d on days 8 and 21)

61

57

80.3

70.5

37.7

6.6

High

Paclitaxel (175 mg/m² on day 1) + Carboplatin (5 mg/ mL*min on day 1) + Endostar (7.5 mg/m²/d on days 8 and 21)

61

58

62.3

59

23

3.3

Johnson [25]

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab (15 mg/kg)

35

57

45.7

80

8.6

11.4

Moderate

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/ mL*min)

32

58

75

81.3

21.9

6.3

Niho [26]

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab (15 mg/kg)

121

61

63.6

68.6

0

0

High

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/ mL*min)

59

60

64.4

71.2

0

0

Patel [27]

Pemetrexed (500 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab (15 mg/kg)

472

65

53.2

89.8

0

0

High

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/ mL*min) + Bevacizumab (15 mg/kg)

467

65

53.3

89.9

0

0

Pereira [28]

Pemetrexed (500 mg/m²) + Carboplatin (5 mg/ mL*min)

106

60

60.4

84.0

0

14.2

Moderate

Docetaxel (75 mg/m²) + Carboplatin (5 mg/mL*min)

105

59

47.6

78.1

0

16.2

Reck [29]

Gemcitabine (1,250 mg/m²) + Cisplatin (80 mg/m²) + Bevacizumab (15 mg/kg)

351

59

62.4

76.6

0

0

High

Gemcitabine (1,250 mg/m²) + Cisplatin (80 mg/m²)

347

59

64.3

76.7

0

–

Sandler [8]

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab (15 mg/kg)

417

56

50.4

74.3

0

0

High

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/ mL*min)

433

58

58.4

77.8

0

0

Scagliotti [30]

Pemetrexed (500 mg/m²) + Cisplatin (75 mg/m²)

862

61

70.2

76.2

40.6

0

Moderate

Gemcitabine (1,000 mg/m²) + Cisplatin (75 mg/m²)

863

61

75.7

75.7

43.5

0

Scagliotti [31]

Gemcitabine (1,250 mg/m²) + Cisplatin (75 mg/m²)

205

63

81.5

81.5

32.7

5.4

Moderate

Vinorelbine (25 mg/m²) + Cisplatin (75 mg/m²)

201

62

78.1

81.1

27.4

8.0

Paclitaxel (225 mg/m²) + Cisplatin (75 mg/m²)

201

62

75.6

81.6

32.3

8.5

Schiller [32]

Gemcitabine (1,000 mg/m²) + Cisplatin

(100 mg/m²)

288

64

62.0

89.0

22.3

6.0

High

Paclitaxel (135 mg/m²) + Cisplatin (75 mg/m²)

288

62

64.0

86.0

26.8

5.0

Docetaxel (75 mg/m²) + Cisplatin (75 mg/m²)

289

63

62.0

86.0

25.0

6.0

Paclitaxel (225 mg/m²) + Carboplatin (6 mg/mL*min)

290

63

63.0

86.0

25.9

5.0

Smit [33]

Gemcitabine (1,250 mg/m²) + Cisplatin (80 mg/m²)

160

57

70.6

78.8

25.6

11.3

High

Paclitaxel (175 mg/m²) + Cisplatin (80 mg/m²)

159

57

59.7

81.8

18.9

11.9

Soria [34]

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/mL*min)

41

62

59

98

49

0

High

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab (15 mg/kg)

44

58

52

95

0

0

Spigel [35]

Ixabepilone (30 mg/m²) + Carboplatin (6 mg/mL*min)

42

63

57

69

47

0

High

Ixabepilone (30 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab(15 mg/kg)

40

63

48

67

3

0

Spigel [36]

Pemetrexed (500 mg/m²) + Carboplatin (5 mg/mL*min) + Bevacizumab (15 mg/kg)

61

73

56

97

0

100

Moderate

Pemerexed (500 mg/m²)

48

72

63

90

0

100

Pemetrexed (500 mg/m²) + Bevacizumab (15 mg/kg)

63

72

57

92

0

100

Treat [37]

Gemcitabine (1,000 mg/m²) + Carboplatin (75 mg/m²)

379

64.1

58.3

90

17.7

0.3

Moderate

Paclitaxel (225 mg/m²) + Carboplatin (6 mg/ mL*min)

379

64.1

60.9

89.4

16.1

0.3

Wu [38]

Pemetrexed (500 mg/m²) + Cisplatin (75 mg/m²)

126

57

56.3

84.9

0

0

High

Gemcitabine (1,250 mg/m²) + Cisplatin (75 mg/m²)

130

56

54.6

84.6

0

0

Zinner [39]

Pemetrexed (500 mg/m²) + Carboplatin (6 mg/mL*min)

182

66

57.5

99.5

0

0

High

Paclitaxel (200 mg/m²) + Carboplatin (6 mg/ mL*min) + Bevacizumab (15 mg/kg)

179

65

58.1

100

0

0

Zhao [40]

Endostar(7.5 mg/ m² on days 1 to 14) + Gemcitabine (1000 mg/m²,days 1 and 8) + Cisplatin ( 30 mg/m²,day 2–4)

33

61

63.4

84.85

45.45

9.09

Moderate

Gemcitabine (1000 mg/m²,days 1 and 8) + Cisplatin ( 30 mg/m²,day 2–4)

36

60

69.44

83.33

52.78

11.11

Zhou [41]

Paclitaxel (175 mg/m²) + Carboplatin (6 mg/mL*min) + Bevacizumab (15 mg/kg)

138

57

54.3

91.3

0

0

High

Paclitaxel (175 mg/m²) + Carboplatin (6 mg/ mL*min)

138

56

55.8

90.6

0

0

Marinis [42]

Bevacizumab (7.5 mg/kg) + Gemcitabine (1,200 mg/m²)

44

74.2

62.8

90.7

0

0

High

Bevacizumab (7.5 mg/k)g + Cisplatin (60 mg/m²) + Gemcitabine (1,000 mg/m²)

42

73.9

70

97.5

0

0

Yu [43]

Gemcitabine (1000 mg/m²) + Carboplatin (5 mg/mL*min)

25

56.7

76

60

56

NA

High

Gemcitabine (1000 mg/m²) + Carboplatin (5 mg/mL*min) + Endostar (7.5 mg/m²)

24

56.3

70.8

62.5

50

NA

Schuette [44]

Bevacizumab (7.5 mg/kg) + Pemetrexed (500 mg/m²)

119

72.3

62.2

95

0

5

High

Bevacizumab (7.5 mg/kg) + Pemetrexed (500 mg/m²) + Carboplatin (5 mg/mL*min)

134

71.9

64.2

95.5

0

5

Zhou [45]

Pemetrexed (500 mg/m²) + Cisplatin (75 mg/m²) + Endostar (7.5 mg/m²)

56

54.1

51.8

87.5

0

0

Moderate

Pemetrexed (500 mg/m²) + Cisplatin (75 mg/m²)

39

57.4

69.2

94.9

0

2.6

Liu [46]

Vinorelbine (25 mg/m²) + Cisplatin (75 mg/m²) + Endostar (7.5 mg/m²)

19

55

57.9

57.o

36.8

5.3

Moderate

Vinorelbine (25 mg/m²) + Cisplatin (75 mg/m²)

34

58.4

52.9

61.8

20.6

11.8

Sun [47]

Endostar (7.5 mg/m² on days 1 to 14) + Vinorelbine (25 mg/m²) + Cisplatin (75 mg/m²)

928

57.5

67.7

69.7

30.5

NA

High

Endostar (7.5 mg/m² on days 1 to 14) + Paclitaxel (150 mg/m²) + Cisplatin (75 mg/m²)

976

55.6

65.9

69.3

31.7

NA

Endostar (7.5 mg/m² on days 1 to 14) + Gemcitabine (800 ~ 1000 mg/m²) + Cisplatin (75 mg/m²)

441

58.1

75.3

71.7

33.1

NA

Endostar (7.5 mg/m² on days 1 to 14) + Gemcitabine (dose unavaliable) + cisplatin (dose unavaliable)

338

59.0

71.3

68.6

29.3

NA