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Fig. 6 | Cancer Cell International

Fig. 6

From: Exosome-transferred hsa_circ_0014235 promotes DDP chemoresistance and deteriorates the development of non-small cell lung cancer by mediating the miR-520a-5p/CDK4 pathway

Fig. 6

CDK4 was a target of miR-520a-5p. a, b The expression of CDK4 at mRNA and proteins in NSCLC tissues and normal tissues was detected by qPCR and western blot. c, d The expression of CDK4 at mRNA and proteins in cancer cells and non-cancer cells was detected by qPCR and western blot. e The correlation between CDK4 expression at the mRNA level and miR-520a-5p expression was analyzed by Spearman’s correlation analysis. f Luciferase reporter plasmids were constructed, and dual-luciferase reporter assay was conducted to validate the relationship between CDK4 and miR-520a-5p. g The efficiency of miR-520a-5p inhibitor was examined by qPCR. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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