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Fig. 7 | Cancer Cell International

Fig. 7

From: Exosome-transferred hsa_circ_0014235 promotes DDP chemoresistance and deteriorates the development of non-small cell lung cancer by mediating the miR-520a-5p/CDK4 pathway

Fig. 7

MiR-520a-5p deficiency aggravated DDP resistance and NSCLC development by upregulating CDK4. a, b The expression of CDK4 at both mRNA and protein levels in A549 and H1299 cells transfected with miR-520a-5p inhibitor, inhibitor NC, miR-520a-5p inhibitor + si-CDK4 or miR-520a-5p inhibitor + si-NC was measured by qPCR and western blot. Then, c cell proliferation, d colony formation ability, e cell cycle progression, f cell invasion, g cell migration and h cell apoptosis in these transfected cells were investigated using CCK-8 assay, colony formation assay, flow cytometry assay, transwell assay, wound healing assay and flow cytometry assay, respectively. i The expression of MMP9, Bax, E-cadherin, Vimentin and MRP-1 in these cells was quantified by western blot. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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