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Fig. 2 | Cancer Cell International

Fig. 2

From: Extracellular vesicle-associated miR-135b and -135a regulate stemness in Group 4 medulloblastoma cells by targeting angiomotin-like 2

Fig. 2

miRNA expression signature of bulk tumour cells (BTCs) and brain tumour spheroid-forming cells (BTSCs) from medulloblastoma patients. Heatmap of miRNA analysis represents the significantly different expression levels of miRNAs in a BTSCs compared with BTCs and b BTSCs-extracellular vesicles (EVs) compared with BTCs-EVs. The colour values display log2 (normalized data). The red or green colour indicates relatively high or low expression, respectively (differences significant with P < 0.05). c Venn diagram showing the unique and overlap of miRNAs between BTSCs (blue) and BTSCs-EVs (pink). d Confirmation of the expression level of miR-135b and miR135a performed by RT-qPCR shows significantly different expression levels in BTSCs compared with BTCs. ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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