Extracellular vesicle-associated miR-135b and -135a regulate stemness in Group 4 medulloblastoma cells by targeting angiomotin-like 2

Table 1 Patient information

Patient no	Gender	Age	Genetic profile	Histology	M stage^a	Location	EOR	Follow-up
1	F	15 y	Medulloblastoma, WNT-activated	Classic	M0	Rt. Cbll	GTR	NED, alive (26 m)
2	M	8 y	Medulloblastoma, SHH-activated	Large cell/anaplastic	M0	Rt. Cbll	GTR	Recurred at 12 m, PD, expired (17 m)
3	F	5 y	Medulloblastoma, SHH-activated	Large cell/anaplastic	M0	Lt. Cbll	GTR	Recurred at 9 m, PD, expired (15 m)
4	M	5 y	Medulloblastoma, group 3	With extensive nodularity	M0	4 V	STR	NED, alive (48 m)
5	M	3 y	Medulloblastoma, group 3	Classic	M3	4 V	GTR	Recurred at 9 m, PD, expired (12 m)
6	M	10 y	Medulloblastoma, group 3	Large cell/anaplastic	M3	4 V	NTR	Recurred at 1 m, PD, alive (42 m)
7	F	12 y	Medulloblastoma, group 4	Large cell/anaplastic	M0	4 V	NTR	NED, alive (23 m)
8	F	7 y	Medulloblastoma, group 4	Classic	M0	4 V	NTR	NED, alive (26 m)
9	M	7 y	Medulloblastoma, group 4	With extensive nodularity	M1	4 V	NTR	Recurred at 22 m, PD, expired (37 m)
10	F	6 y	Medulloblastoma, group 4	Classic	M0	4 V	GTR	NED, alive (15 m)

F female, M male, y years, MBEN medulloblastoma with extensive nodularity, Cbll cerebellum, 4V fourth ventricle, EOR extent of resection, GTR gross total resection, STR subtotal resection, NTR near total resection, m months, NED no evidence of disease, PD progressive disease
^a M stage (Chang’s classification) [47]. M0: no metastasis; M1: presence of tumor cells in the CSF; M2: nodular seeding in the cerebellar or cerebral subarachnoid space or in the third or lateral ventricle; M3: metastasis in spinal subarachnoid space; M4: metastases outside the cerebrospinal axis

ISSN: 1475-2867