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Fig. 3 | Cancer Cell International

Fig. 3

From: Exosomal miR-126 blocks the development of non-small cell lung cancer through the inhibition of ITGA6

Fig. 3

Exosomal miR-126 suppressed NSCLC cell malignant behaviors in vitro. a The expression of miR-126 in serum-derived exosomes from NSCLC patients and healthy controls was detected by qRT-PCR. b The expression of miR-126 in A549, H460 and HBE cells was measured by qRT-PCR. c The efficiency of miR-126 mimic in exosomes was examined using qRT-PCR. d A549 and H460 cells were co-cultured with NSCLC serum-derived exosomes transfected with miR-126 or miR-NC. In these cells, e, f cell cycle was investigated using flow cytometry assay. g The ability of colony formation was assessed by colony formation assay. h, i Cell proliferation was monitored by MTT assay. j, k Cell migration and cell invasion were detected using transwell assay. l, m The expression of E-cadherin, N-cadherin and Vimentin was determined by western blot. n Cell apoptosis was evaluated by flow cytometry assay. *P < 0.05

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