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Fig. 4 | Cancer Cell International

Fig. 4

From: Exosomal miR-126 blocks the development of non-small cell lung cancer through the inhibition of ITGA6

Fig. 4

MiR-126 directly bound to ITGA6. a The binding site between miR-126 and ITGA6 3′UTR was analyzed by miRDB website. b, c The relationship between miR-126 and ITGA6 was validated by dual-luciferase reporter assay. d, e The relationship between miR-126 and ITGA6 was validated by RIP assay. f The efficiency of miR-126 mimic and miR-126 inhibitor was examined using qRT-PCR. g, h The effects of miR-126 mimic and miR-126 inhibitor on the expression of ITGA6 was determined by qRT-PCR and western blot. i, j The expression of ITGA6 in serum-derived exosomes from NSCLC patients and healthy controls was detected by qRT-PCR and western blot. k, l The expression of ITGA6 in HBE, A549 and H460 cells was detected by qRT-PCR and western blot. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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