Fig. 7
The in vivo effects of parthenolide in NSCLC xenograft therapy model. a Nude mice were inoculated with 2.5 million H1975 cells, subcutaneously, into their flanks. a Tumor growth curve for H1975 cells xenografts mouse model, when tumors reached ~ 60 mm3, mice were randomized into treatment cohorts: vehicle, 20 mg/kg/d parthenolide by ip. Tumor measurements were performed one time per 3 days by calipers, the results were reported as tumor volume (mm3) ± SEM. ***P < 0.001, vs. vehicle–treated group. b The average tumor weight of control group and the parthenolide-treated tumor at harvest day (day 15). c Quantification of body weight for each group. d Images represent hematoxylin & eosin (H&E) and immunohistochemical staining for p-EGFR, p-ERK, p-AKT, Ki-67 and cleaved caspase-3 antibody, scale bar, 100 µm. *P < 0.05. **P < 0.01. ***P < 0.001 for comparison vehicle