Fig. 3

Resveratrol, curcumin and paclitaxol affects the mTOR pathway at several stages from inhibition to PI3K to suppression of Akt signaling to prevent the mTORC1 and mTORC2 complexes. Paclitaxol also stabilizes P53 which promotes complex formation of TSC1 and TSC2. TSC1/2 complex then represses mTOR signaling. These compounds mediated inhibition of mTOR complexes results in the apoptosis and stop of bladder cancer growth