Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer

Table 1 List of miRNAsand their target genes, along with their expression in bladder cancer

miRNA	Target gene	Expression	BC cell line		References
miRNA	Target gene	Expression	Name	Type	References
miR-103	PTEN	Up-regulated	UMUC2, 5637		[60]
miR-146a	AMPKα	Up-regulated	T24, 5637	Muscle invasive	[66]
miR-21	PTEN	Up-regulated	T24, 5637	Muscle invasive	[103]
miR-224	PTEN	Up-regulated	EJ, T24, 253 J, RT4, TCC-SUP, UMUC, J82, 5637		[68]
miR-218	BMI-1	Up-regulated	T24, EJ		[69]
miR-222	PPAR2A	Up-regulated	T24, 5637		[70]
miR-99a-5p	S6KI	Down-regulated	J82, HT‐1376, 5637, RT4, and T24		[62]
miR-100	PTEN	Down-regulated	CaBER, BIU-87, 5637, T24, T4, J82, HT-1376, EJ, TCCSUP, SV4		[65]
miR-126	PI3KR2	Down-regulated	BLS		[71]
miR-125-5p	Hexokinase2	Down-regulated	T24, RT4, J82, 5637		[73]

ISSN: 1475-2867