Fig. 2

Knockdown of circ_0015756 inhibits the proliferation, migration and invasion of OC cells and induces apoptosis. OV90 and SKOV3 cells were transfected with si-NC or si-circ_0015756, respectively. a The knockdown efficiency of circ_0015756 was determined by qRT-PCR. b, c Cell viability was detected using CCK-8 assay. d Cell proliferation ability was estimated by colony formation assay. e, f The levels of proliferation-related proteins (Ki67 and CDK2) were measured by Western blot. g Flow cytometry was used to detect the proportion of apoptotic cells. h, i Cell migration and invasion capacities were tested by transwell assay (magnification: 100×). j, k The levels of migration and invasion-associated proteins (Snail and MMP9) were examined by Western blot. *P < 0.05