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Fig. 2 | Cancer Cell International

Fig. 2

From: Inhibition of cancer cell-derived exosomal microRNA-183 suppresses cell growth and metastasis in prostate cancer by upregulating TPM1

Fig. 2

Overexpression of miR-183 promoted cell proliferation and invasion in prostate cancer. Determination of miR-183 expression in prostate cancer by RT-qPCR assay, showing high expression of miR-183 in RWPE-1, LNCAP, and PC3 cells. *p < 0.05 vs. RWPE-1 cells, #p < 0.05 vs. LNCAP cells. b Determination of miR-183 expression following overexpression and inhibition of miR-183 in LNCAP and PC3 cells by RT-qPCR assay. c Cell viability examined by MTT assay. d, e Transwell assay for the detection of the effect of miR-183 on cell migration, blue indicates the migrated cells. f, g Transwell assay for the detection of the effect of miR-183 on cell invasion, blue indicates the invaded cells *p < 0.05 vs. mimic-NC group, #p < 0.05 vs. inhibitor-NC group. The miR-183-mimic group, miR-183-inhibitor group, mimic-NC group, and inhibitor-NC group referring to LNCaP or PC3 cells respectively transfected with miR-183 mimic, miR-183 inhibitor, mimic-NC, inhibitor-NC. Cell experiments were repeated three times

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