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Fig. 4 | Cancer Cell International

Fig. 4

From: Inhibition of cancer cell-derived exosomal microRNA-183 suppresses cell growth and metastasis in prostate cancer by upregulating TPM1

Fig. 4

Exosomes derived from PC3 cells can be taken up by LNCaP cells. a Exosomes derived from PC3 cells were observed under a transmission electron microscope (× 5000). The size and morphology of vesicles were not uniform. b Detection of exosome diameter by DLS. c The expression of HSP70 and CD63 measured by Western blot analysis, the content of both proteins in exosomes higher than that in supernatant, lane 1 indicates exosome and lane 2 indicates cell. d The content of CD63 examined by flow cytometry. e The image of laser confocal microscopy. Exosomes derived from PC3 cells labeled by CFSE (green fluorescence) could be delivered into LNCAaP cells (× 400). Measurement data were expressed as mean ± standard deviation. Comparison between two groups was analyzed by unpaired t-test. Each experiment was repeated three times

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