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Fig. 6 | Cancer Cell International

Fig. 6

From: Inhibition of cancer cell-derived exosomal microRNA-183 suppresses cell growth and metastasis in prostate cancer by upregulating TPM1

Fig. 6

PC3 cells-derived exosomal miR-183 promotes the development of prostate cancer through downregulation of TPM1. a Expression of TPM1 in LNCaP cells detected by Western blot analysis. b Detection for proliferation in LNCaP cells by CCK-8 assay. c, d Detection for migration and invasion in LNCaP cells by Transwell assay (× 200). *p < 0.05 vs. si-NC group, #p < 0.05 vs. oe-NC group. The oe-TPM1 group, si-TPM1 group, oe-NC group, and si-NC group refer to LNCaP cells transfected with oe-TPM1, si-TPM1 and their negative controls. The exo-miR-183-inhibitor + si-TPM1 group and exo-miR-183-inhibitor + si-NC group refer to si-TPM1 transfected-LNCaP cells co-cultured with exosome derived from PC3 cells transfected with miR-183-inhibitor and si-TPM1, The exo-miR-183-inhibitor + si-NC group refers to si-NC transfected-LNCaP cells co-cultured with exosome derived from PC3 cells transfected with miR-183-inhibitor. Measurement data were expressed as mean ± standard deviation. Comparisons among multiple groups were conducted by one-way analysis of variance (ANOVA) with Tukey’s post hoc test. Statistical analysis in relation to time-based measurements within each group was realized using repeated measurement ANOVA, followed by a Bonferroni’s post-hoc test. n = 6

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