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Fig. 7 | Cancer Cell International

Fig. 7

From: YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas

Fig. 7

The relationship between YAP and PTEN/AKT/mTOR-mediated autophagy. When the Hippo pathway is revitalite, the activation of core Hippo pathway kinases (MST1/2, SAV1, MOB1A/B or LATS1/2) are ON, and YAP is phosphorylated and cytoplasmically retained by 14-3-3 for degradation. Above process enhancing autophagy by inhibiting AKT/mTOR pathway via elevating PTEN activation, the increase in autophagy further suppressing the non-small cell lung cancer cells proliferation. Once Hippo pathway is inactivated, YAP overexpression inhibits the activity of PTEN, which blocks the AKT/mTOR-mediated autophagy signaling pathway, promoting the proliferation of non-small cell lung cancer cells. Thus, Hippo pathway critical transcriptional coactivators YAP manipulates the proliferation of lung adenocarcinoma, which is regulated by PTEN/AKT/mTOR autophagic signaling

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