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Fig. 1 | Cancer Cell International

Fig. 1

From: Berberine reduces temozolomide resistance by inducing autophagy via the ERK1/2 signaling pathway in glioblastoma

Fig. 1

Berberine resensitizes TMZ resistance cells to TMZ in GBM cells. a and b Parental and TMZ resistance cells were treated with increasing concentrations of TMZ for 24, 48 72 h. Cell viability was analyzed by MTT assay. c and d TMZ resistance cells were treated with TMZ with or without 10 μM berberine for 72 h. Cell viability was analyzed by MTT assay. e and f TMZ resistance cells were treated with 100 μM TMZ with or without 10 μM berberine for 72 h. Apoptosis was analyzed flow cytometry. g and h Parental and TMZ resistance cells were treated with 100 μM TMZ with or without 10 μM berberine as indicated for 24 h. Cleaved caspase 3 was analyzed by western blotting and normalized to β-actin. BBR: berberine. Results were presented as means ± SD from three independent experiments. **, P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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