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Fig. 6 | Cancer Cell International

Fig. 6

From: LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis

Fig. 6

MiR-139-3p inhibitor reversed the inhibitory effect of shPCAT6 on BRD4 expression, and the viability and proliferation of PA cells. a, c The expressions of BRD4 in RC-4B/C and GH3 cells after ransfection were detected by RT-qPCR. GAPDH was used as an internal control. b, d The expressions of BRD4 in RC-4B/C and GH3 cells after transfection were detected by Western blot. GAPDH was used as an internal control. e, f The viability of RC-4B/C and GH3 cells after transfection was detected by CCK-8 assay. gi The proliferation of RC-4B/C and GH3 cells after transfection was detected by colony formation assay. (***P < 0.001, vs. MC + shNC; ##P < 0.01, ###P < 0.001, vs. IC + shNC; ^^^P < 0.001, vs. I + shNC; P < 0.05, ▲▲P < 0.01, ▲▲▲P < 0.001, vs. shPCAT6 + IC). M: miR-139-3p mimic, MC mimic control, I miR-139-3p inhibitor, IC inhibitor control, shNC shRNA negative control

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