Fig. 1

Bioinformatics analysis predicting the DEGs and their molecular interactions in CRC. a The intersection of the top 100 DEGs with the largest fold change between GSE89076 and GSE41328 datasets, revealing 15 intersected genes. b The intersection of CRC genes between Digsee and DisGeNET, showing 17 intersected genes. c The PPI network of DEGs and disease genes; the diamonds refer to DEGs and the circles to disease genes. d A heatmap of the top 100 genes with largest fold change in dataset GSE89076; the X-axis refers to sample number and the Y-axis to DEGs; the histogram in upper right indicates changes by color gradation, where each rectangle corresponds to a sample’s expression value. e The expression level of ETV4 in CRC and matched normal colonic tissues in dataset GSE41328. f The intersection of miRNAs that could bind to ETV4 predicted by the TargetScan, DIP, miRWalk, microRNA and miRpath databases, showing has-miR-29b-3p at the intersection