Fig. 3

Circ_ZFR sponged miR-195-5p to negatively regulate miR-195-5p expression. a The potential binding sites between circ_ZFR and miR-195-5p were shown. b, c The interaction between circ_ZFR and miR-195-5p in A549/PTX and H460/PTX cells was determined by dual-luciferase reporter assay. d The expression level of miR-195-5p in si-NC or si-circ_ZFR transfected A549/PTX and H460/PTX cells was examined by qRT-PCR analysis. e QRT-PCR assay was used to determine miR-195-5p level in HBE, A549, H460, A549/PTX and H460/PTX cells. f QRT-PCR assay was used for miR-195-5p level in normal tissues, PTX-sensitive and PTX-resistant NSCLC tissues. g, h The correlation between circ_ZFR and miR-195-5p in PTX-sensitive and PTX-resistant tumor tissues was estimated by spearman’s correlation coefficient analysis. *P < 0.05