Table 3 Biomarker research of circRNAs in cancers
From: Cancer-related circular RNA: diverse biological functions
Cancer type | CircRNA | Existence | Expression | Clinical Value | Ref. |
|---|---|---|---|---|---|
Gastric cancer | hsa_circRNA_102958 | Tissue | Up | Diagnosis | [105] |
hsa_circ_0074362 | Down | [106] | |||
hsa_circ_0003159 | Down | [107] | |||
hsa_circ_0000190 | Tissue and plasma | Down | [108] | ||
circPSMC3 | Down | [78] | |||
circ-KIAA1244 | Down | [109] | |||
hsa_circ_0000520 | Down | [110] | |||
circ-DCAF6 | Tissue | Up | Prognosis | [111] | |
circPDSS1 | Up | [112] | |||
circ-DONSON | Up | [76] | |||
circLMTK2 | Down | [112] | |||
circLARP4 | Down | [113] | |||
hsa_circ_0001895 | Down | Diagnosis and prognosis | [114] | ||
hsa_circ_0065149 | Plasma exosome | Down | [115] | ||
Colorectal cancer | circRNA_0001178 | Tissue | Up | Diagnosis | [93] |
circRNA_0000826 | Up | [93] | |||
circVAPA | Tissue and plasma | Up | [116] | ||
hsa_circ_0004585 | Tissue and peripheral blood | Up | [117] | ||
circDDX17 | Tissue | Down | [118] | ||
circRNA0003906 | Down | [119] | |||
hsa_circ_001988 | Down | [120] | |||
circ-ITGA7 | Down | [90] | |||
circHIPK3 | Up | Prognosis | [89] | ||
circCCDC66 | Up | [45] | |||
circ_0026344 | Down | [121] | |||
Lung cancer | circRNA_102231 | Tissue | Up | Diagnosis | [122] |
hsa_circ_0014130 | Up | [123] | |||
hsa_circ_0001946 | Down | [124] | |||
hsa_circ_0033155 | Down | [125] | |||
circ_0067934 | Up | Prognosis | [126] | ||
hsa_circ_0000792 | Up | [127] | |||
hsa_circRNA_103809 | Up | [128] | |||
circARHGAP10 | Up | [83] | |||
circTP63 | Up | [84] | |||
circRNA_100876 | Up | [129] | |||
Hepatoma | circFBLIM1 | Tissue | Up | Diagnosis | [63] |
circRNA_100338 | Up | [54] | |||
hsa_circ_0005075 | Up | [61] | |||
hsa_circ_0091579 | Up | Diagnosis and prognosis | [130] | ||
hsa_circ_0128298 | Up | [131] | |||
hsa_circ_0078602 | Down | [132] | |||
circ-0051443 | Plasma exosomes and tissues | Down | Diagnosis | [71] | |
Breast cancer | circGFRA1 | Tissue | Up | Diagnosis | [133] |
hsa_circ_0072309 | Up | Prognosis | [134] | ||
circKIF4A | Up | [135] | |||
CircEPSTI1 | Up | [72] | |||
circ-ITCH | Down | [136] | |||
circKDM4C | Down | [137] | |||
Bladder cancer | hsa_circ_0018069 | Tissue | Down | Diagnosis | [138] |
circPRMT5 | Tissue serum and urine exosome | Up | Prognosis | [139] | |
circLPAR1 | Tissue | Down | [140] | ||
circMTO1 | Down | [141] | |||
hsa_circ_0000285 | Tissue and serum | Down | [142] | ||
Osteosarcoma | circPVT1 | Tissue and serum | Up | Diagnosis | [143] |
circ_HIPK3 | Tissue | Down | [144] | ||
hsa_circ_0002052 | Down | Prognosis | [145] | ||
hsa_circ_0081001 | Tissue and serum | Up | Diagnosis and prognosis | [146] | |
Esophageal squamous cell carcinoma | hsa_circ_0006168 | Tissue | Up | Diagnosis | [147] |
cicrRNA_100876 | Up | Prognosis | [100] | ||
hsa_circ_0067934 | Up | PROGNOSIS | [148] | ||
Leukemia | hsa_circ_0004277 | Tissue | Down | Diagnosis | [149] |
circ-CBFB | Up | Diagnosis and prognosis | [150] | ||
Glioma | cir-ITCH | Tissue | Down | Diagnosis and Prognosis | [151] |
circCPA4 | Tissue | Up | Prognosis | [91] | |
Nasopharyngeal carcinoma | circRNA_0000285 | Tissue and serum | Up | Prognosis | [152] |
Oral squamous cell carcinoma | hsa_circ_001242 | Tissue | Down | Diagnosis | [153] |
Cholangiocarcinoma | Cdr1as | Tissue | Up | Prognosis | [154] |
Pancreatic cancer | circ-LDLRAD3 | Tissue and plasma | Up | Diagnosis | [155] |
Papillary thyroid carcinoma | hsa_circ_0137287 | Tissue | Down | Diagnosis | [156] |
Cervical cancer | circRNA8924 | Tissue | Up | Diagnosis | [157] |