Fig. 8

Effect of miR-532-3p targeting HMGA2 on proliferation of CRC cells. a, b siHMGA2 and miR-532-3p mimic inhibited HMGA2 expression, HMGA2 overexpression plasmid and miR-532-3p inhibitor had the opposite effects. c, d The effect of miR-532-3p and HMGA2 on cell migration was examined by CCK-8 experiment. e–h miR-532-3p inhibitor, HMGA2 overexpression promoted cell proliferation; miR-532-3p mimic, silencing HMGA2 inhibited cell proliferation. i, l The effects of miR-532-3p and HMGA2 on cell migration were detected by scratch experiments. ^**P < 0.01, ^***P < 0.001 vs IC + siNC; ^##P < 0.01, ^###P < 0.001 vs I + siNC; ^{^^^}P < 0.001 vs IC + siHMGA2; ^&&P < 0.01, ^&&&P < 0.001 vs MC + NC; ^△△△P < 0.001 vs MC + HMGA2; ⁺⁺⁺P < 0.001 vs M + NC