Expression levels of gene | Grade | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Crude OR (95%CI) | Adjusted OR (95%CI) | ||||||||||||
N | I | II | II | P-value¥ | I | II | III | P for trend | I | II | III | P for trend | |
CTTN | |||||||||||||
<2.31* | 72 | 22 (30.6)a | 42 (58.3) | 8 (11.1) | 0.027 | 1.00 | 3.03 (1.30–7.08)b | 3.02 (0.93–9.82) | 0.03 | 1.00 | 3.37 (1.35–8.38)c | 3.69 (1.08–12.61) | 0.020 |
≥2.31 | 77 | 10 (12.7) | 58 (73.4) | 11 (13.9) | |||||||||
<4.88** | 86 | 26 (30.2) | 50 (58.1) | 10 (11.6) | 0.007 | 1.00 | 4.33 (1.64–11.43) | 3.90 (1.10–13.81) | 0.016 | 1.00 | 5.08 (1.75–14.69)c | 5.08 (1.32–19.44) | 0.010 |
≥4.88 | 65 | 6 (9.2) | 50 (76.9) | 9 (13.8) | |||||||||
RhoA | |||||||||||||
<0.69* | 86 | 22 (25.6) | 55 (64.0) | 9 (10.5) | 0.238 | 1.00 | 1.77 (0.82–3.79) | 2.27 (0.76–6.69) | 0.107 | 1.00 | 1.81 (0.83–3.96)d | 2.58 (0.86–7.76) | 0.073 |
≥0.69 | 89 | 14 (15.7) | 62 (69.7) | 13 (14.6) | |||||||||
<0.73** | 87 | 22 (25.3) | 55 (63.2) | 10 (11.5) | 0.305 | 1.00 | 1.77 (0.82–3.79) | 1.88 (0.64–5.51) | 0.184 | 1.00 | 1.81 (0.83–3.96)d | 2.14 (0.72–6.38) | 0.131 |
≥0.73 | 88 | 14 (15.9) | 62 (70.5) | 12 (13.6) | |||||||||
ROCK | |||||||||||||
<0.83* | 85 | 21 (24.7) | 55 (64.7) | 9 (10.6) | 0.347 | 1.00 | 1.66 (0.77–3.58) | 2.00 (0.66–5.99) | 0.172 | 1.00 | 1.65 (0.76–3.58)e | 1.90 (0.63–5.74) | 0.202 |
≥0.83 | 87 | 14 (16.1) | 61 (70.1) | 12 (13.8) | |||||||||
<1.09** | 105 | 28 (26.7) | 67 (63.8) | 10 (9.5) | 0.025 | 1.00 | 2.92 (1.18–7.24) | 4.40 (1.33–14.48) | 0.011 | 1.00 | 2.86 (1.14–7.14)e | 4.22 (1.26–14.07) | 0.014 |
≥1.09 | 67 | 7 (10.4) | 49 (73.1) | 11 (16.4) | |||||||||
CLDN-1 | |||||||||||||
<1.06 * | 87 | 19 (21.8) | 56 (64.4) | 12 (13.8) | 0.491 | 1.00 | 1.27 (0.60–2.69) | 0.74 (0.24–2.25) | 0.806 | 1.00 | 1.35 (0.63–2.89)f | 0.78 (0.25–2.40) | 0.891 |
≥1.06 | 89 | 17 (19.1) | 64 (71.9) | 8 (9.0) | |||||||||
<0.75** | 38 | 7 (18.4) | 25 (65.8) | 6 (15.8) | 0.614 | 1.00 | 0.91 (0.36–2.33) | 0.56 (0.15–1.99) | 0.420 | 1.00 | 0.96 (0.37–2.48)f | 0.57 (0.16–2.04) | 0.452 |
≥0.75 | 138 | 29 (21.0) | 95 (68.8) | 14 (10.1) | |||||||||
CLDN-2 | |||||||||||||
<1.15* | 47 | 13 (27.7) | 29 (61.7) | 5 (10.6) | 0.434 | 1.00 | 1.90 (0.69–5.23) | 1.95 (0.44–8.54) | 0.275 | 1.00 | 2.56 (0.79–8.34)g | 2.99 (0.57–15.51) | 0.143 |
≥1.15 | 48 | 8 (16.7) | 34 (70.8) | 6 (12.5) | |||||||||
<1.12** | 16 | 6 (37.5) | 8 (50.0) | 2 (12.5) | 0.241 | 1.00 | 2.75 (0.82–9.15) | 1.80 (0.29–10.90) | 0.269 | 1.00 | 2.97 (0.84–10.44)g | 2.04 (0.32–12.94) | 0.243 |
≥1.12 | 79 | 15 (19.0) | 55 (69.6) | 9 (11.4) | |||||||||
CLDN-4 | |||||||||||||
<0.85* | 86 | 17 (19.8) | 59 (68.6) | 10 (11.6) | 0.963 | 1.00 | 0.91 (0.43–1.92) | 0.84 (0.33–2.89) | 0.930 | 1.00 | 0.93 (0.43–2.01)h | 1.04 (0.35–3.12) | 0.980 |
≥0.85 | 90 | 19 (21.1) | 60 (66.7) | 11 (12.2) | |||||||||
<0.67** | 68 | 14 (20.6) | 47 (69.1) | 7 (10.3) | 0.866 | 1.00 | 0.97 (0.45–2.09) | 1.27 (0.41–3.93) | 0.740 | 0.98 (0.45–2.14)h | 1.32 (0.42–4.12) | 0.687 | |
≥0.67 | 108 | 22 (20.4) | 72 (66.7) | 14 (13.0) |