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Table 5 Univariate linear regression analysis (standardized β coefficient) between the studied genes of tumors of study population of BrCa (N = 206)

From: Profiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer

  CTTN (n = 174) RhoA (n = 205) ROCK (n = 202) CLDN-1 (n = 206) CLDN-2 (n = 110) CLDN-4 (n = 206)
Total population
CTTN 1      
RhoA 0.065 (0.395)* 1     
ROCK 0.170 (0.028) 0.246 (< 0.001) 1    
CLDN-1 − 0.036 (0.646) − 0.007 (0.917) − 0.062 (0.391) 1   
CLDN-2 0.043 (0.686) − 0.017 (0.866) 0.237 (0.014) 0.034 (0.727) 1  
CLDN-4 0.013 (0.868) 0.086 (0.228) − 0.023 (0.752) 0.411 (< 0.001) − 0.102 (0.292) 1
ER- and PR ± (n = 23)
CTTN 1      
RhoA 0.182 (0.465) 1     
ROCK 0.398 (0.091) 0.397 (0.067) 1    
CLDN-1 0.198 (0.415) 0.009 (0.967) − 0.049 (0.832) 1   
CLDN-2 0.655 (0.029) − 0.247 (0.465) − 0.285 (0.396) − 0.316 (0.344) 1  
CLDN-4 − 0.027 (0.914) 0.077 (0.748) 0.007 (0.975) 0.095 (0.691) − 0.366 (0.299) 1
ER + and PR ± (n = 158)
CTTN 1      
RhoA 0.074 (0.404) 1     
ROCK 0.128 (0.153) 0.280 (0.001) 1    
CLDN-1 -0.065 (0.469) − 0.001 (0.994) − 0.066 (0.433) 1   
CLDN-2 0.033 (0.786) − 0.005 (0.965) 0.267 (0.016) 0.020 (0.858) 1  
CLDN-4 0.016 (0.859) 0.086 (0.301) − 0.015 (0.862) 0.451 (< 0.001) − 0.119 (0.284) 1
ALNM– (n = 64)       
CTTN 1      
RhoA − 0.056 (0.705) 1     
ROCK − 0.049 (0.741) 0.233 (0.083) 1    
CLDN-1 0.070 (0.638) 0.011 (0.932) − 0.166 (0.217) 1   
CLDN-2 − 0.041 (0.847) 0.166 (0.382) 0.733 (< 0.001) − 0.045 (0.810) 1  
CLDN-4 0.022 (0.882) 0.103 (0.446) − 0.194 (0.151) 0.522 (< 0.001) − 0.131 (0.490) 1
ALNM + (n = 120)
CTTN 1      
RhoA 0.129 (0.204) 1     
ROCK 0.226 (0.027) 0.311 (0.001) 1    
CLDN-1 − 0.079 (0.448) − 0.010 (0.921) 0.040 (0.681) 1   
CLDN-2 0.121 (0.384) − 0.160 (0.219) − 0.098 (0.443) 0.004 (0.976) 1  
CLDN-4 0.030 (0.769) 0.068 (0.479) 0.029 (0.763) 0.377 (< 0.001) − 0.028 (0.826) 1
Stage I (n = 55)
CTTN 1      
RhoA 0.060 (0.710) 1     
ROCK 0.519 (0.001) 0.252 (0.077) 1    
CLDN-1 − 0.025 (0.877) − 0.060 (0.674) − 0.115 (0.422) 1   
CLDN-2 − 0.064 (0.766) 0.204 (0.298) 0.741 (< 0.001) − 0.049 (0.800) 1  
CLDN-4 0.232 (0.144) 0.039 (0.758) 0.002 (0.990) 0.389 (0.004) − 0.136 (0.480) 1
Stages II-III (n = 126)
CTTN 1      
RhoA 0.098 (0.329) 1     
ROCK 0.069 (0.496) 0.308 (0.001) 1    
CLDN-1 0.002 (0.980) 0.022 (0.818) 0.002 (0.987) 1   
CLDN-2 0.130 (0.359) − 0.163 (0.213) − 0.130 (0.324) 0.013 (0.923) 1  
CLDN-4 − 0.052 (0.609) 0.085 (0.375) − 0.019 (0.842) 0.429 (< 0.001) − 0.014 (0.917) 1
  1. The statistically significant finding is shown in italics (P < 0.05)
  2. N number, CTTN cortactin, RhoA ras homolog gene family member A, ROCK rho-associated kinase, CLDN claudin, ER estrogen receptor, PR progesterone receptor, ALNM axillary lymph node metastasis
  3. *Data were expressed as standardized β coefficient (P-value)