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Table 1 The subtypes of breast cancer classified via expression of Ki67 and hormonal status

From: MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer

Subtypes The expression of Ki67 and hormonal status
Luminal A Estrogen positive (ER +)
Progesterone receptor (PR) ≥ 20%
HER2 negative (HER2-)
Ki67 < 14%
Luminal B (HER2−) Estrogen positive (ER +)
HER2 negative (HER2-)
Ki67 ≥ 20%
Progesterone receptor (PR) < 20% or progesterone receptor negative (PR-)
Luminal B (HER2+) Any progesterone receptor (PR) level
Any Ki67 level
HER2 positive (HER2+)
Estrogen positive (ER+)
HER2 positive (HER2+) (non-luminal) HER2 positive (HER2+)
Estrogen negative (ER-)
Progesterone negative (PR−)
Triple-negative breast cancer (TNBC) HER2 negative (HER2−)
Estrogen negative (ER−)
Progesterone negative (PR−)