Table 2 miRNA acts as suppressor in breast cancer
From: MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
miRNA | Target | Result on BCSCs |
|---|---|---|
miR-7 | KLF4 | Inhibits self-renewal, pluripotent potential metastatic and invasive ability of BCSCs |
miR-93 | HMGA2 | Â |
AKT3 | Â | |
EZH1 | Suppresses EMT and metastasis | |
JAK1 | Inhibits differentiation and proliferation of BCSCs | |
SOX4 | Â | |
STAT3 | Â | |
miR-30 | UBC9 | Inhibits self-renewal ability of BCSCs |
ITGB3 | Induces apoptosis of BCSCs | |
miR-590-5p | SOX2 | Inhibits stemness, metastasis, population and tumorigenicity of BCSCs |
miR-140 | ALDH1 | Reduces stemness phenotypes of BCSCs |
SOX9 | Inhibits tumor growth and formation in vivo | |
miR-16 | Wip1 | Inhibits growth and self-renewal capacity of BCSCs |
miR-130-3p | RAB5B | Represses proliferation, migration and invasion of BCSCs |
miR-4319 | E2F2 | Inhibits tumorigenicity and self-renewal of BCSCs |
miR-519d | MCL-1 | Suppresses BCSCs’ chemoresistance to cisplatin |
miR-375 | HOXB3 | Inhibits stemness phenotypes, EMT, migration and invasion of BCSCs |