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Fig. 5 | Cancer Cell International

Fig. 5

From: Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells

Fig. 5

MG co-treatment enhances cytotoxicity. a Fluorescence microscopy showing GFP-Ub after VP exposure (10 µM) for 24 h. Scale bar: 100 µm. b Fluorescence microscopy showing RFP-Ub upon VP (10 µM) only, or VP and MG (0.5 µM) treatment for 24 h. c (i) Bar graph representing fold change in intracellular ROS levels post-exposure to VP only, or VP plus MG for 24 h. (ii) MTT assay analyzing cell viability after 24 h of VP or VP plus MG treatment in the presence or absence of NAC. *, # and $ indicate the significant difference with respect to control, VP with VP + MG, or between NAC+ and NAC− cells, respectively. d Flow cytometric analysis showing PI+ve cells after VP (10 µM) and/or VP plus MG (0.5 µM) treatment for 24 h

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