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Fig. 4 | Cancer Cell International

Fig. 4

From: Anlotinib as a promising inhibitor on tumor growth of oral squamous cell carcinoma through cell apoptosis and mitotic catastrophe

Fig. 4

Expression of VEGFR2, cell-cycle-related and apoptosis-related protein was visualized by western blot. Anlotinib inhibited the expression of VEGFR2 on cell line Cal-27 and SCC-25 (a). Key checkpoint biomarkers such as phosphorylated-Chk-2, phosphorylated-Cdc-2 and Cyclin B1 was down-regulated after Anlotininb administration. Phosphorylated histone 3 was upregulated in anlotinib-treated group (b). Expression of such apoptotic biomarkers as Bax, Cleaved-Caspase-3 and Cleaved-PARP increased in Anlotinib-treated groups. Bcl-2 was downregulated in expression (c)

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