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Fig. 3 | Cancer Cell International

Fig. 3

From: miR-636 inhibits EMT, cell proliferation and cell cycle of ovarian cancer by directly targeting transcription factor Gli2 involved in Hedgehog pathway

Fig. 3

miR-636 directly targets Gli2, inhibits the activation of the Hh signaling pathway and suppresses EMT. a The binding sites of miR-636 on Gli2 3′UTR were predicted by TargetScan database; b Relative protein expression of Gli2 after miR-636 was overexpressed or inhibited; c The targeting relationship between miR-636 and Gli2 was verified by dual-luciferase assay; d qRT-PCR was performed to detect the expression of miR-636, Hh and EMT markers in OVC cells with the overexpression or inhibition of miR-636, while e Western blot was conducted to examine the protein expression of Hh and EMT markers; *p < 0.05, **p < 0.01

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Cancer Cell International

ISSN: 1475-2867

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