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Fig. 1 | Cancer Cell International

Fig. 1

From: Downregulation of tumor‐derived exosomal miR-34c induces cancer‐associated fibroblast activation to promote cholangiocarcinoma progress

Fig. 1

Exosomes secreted from cancer cells regulate activation of fibroblasts. a qRT-PCR analysis of expression of pro-inflammatory genes—IL-1β, IL-6, and IL-8—in CCC-HSF-1 cells treated with exosomes from HuCCT-1 or HIBEC cells. b Western blotting analysis of fibroblast activation proteins—α-SMA and FAP. c Migration assay for CCC-HSF-1 cells treated with equal quantities of exosomes derived from tumor or normal cells; Scale bar, 50 μm. d Confocal imaging of Dio-labeled (green) exosomes incubated with Dil-labeled (red) fibroblasts; Scale bar, 10 µm. Error bars, SD. *P < 0.05, **P < 0.01

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