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Fig. 4 | Cancer Cell International

Fig. 4

From: Downregulation of tumor‐derived exosomal miR-34c induces cancer‐associated fibroblast activation to promote cholangiocarcinoma progress

Fig. 4

Inhibition of miR-34c restores Wnt signaling pathway and activates fibroblasts. a-c qRT-PCR, western blotting, and migration assay analyses to assess expression of pro-inflammatory genes, protein levels of α-SMA and FAP, and cell migration, respectively, in CCC-HSF-1 cells treated with or without miR-34c inhibitor. d-f qRT-PCR, western blotting, and cell migration assay analyses to detect expression of pro-inflammatory genes, levels of fibrinogen and Wnt pathway-related proteins, and cell migration, respectively, in CCC-HSF-1 cells treated with or without si-WNT1 and CCA-Exo; Scale bar, 50 µm. *P < 0.05, **P < 0.01 vs. inhibitor NC or si-Ctrl groups

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Cancer Cell International

ISSN: 1475-2867

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