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Fig. 7 | Cancer Cell International

Fig. 7

From: Downregulation of tumor‐derived exosomal miR-34c induces cancer‐associated fibroblast activation to promote cholangiocarcinoma progress

Fig. 7

Activated fibroblast affects cell proliferation and migration via miR-34c–WNT1 axis. Cell proliferation and migration have been assessed in multiple cell types in co-cultures—QBC939 cells treated with supernatant of CCC-HSF-1 cells treated with miR-34c inhibitor or si-WNT1. a-c MTT and migration assay analysis to assess cell proliferation and migration in QBC939 cells treated with or without miR-34c inhibitor. d-f MTT and migration assay analysis to detect cell proliferation and migration in QBC939 cells treated with or without si-WNT1 + CCA-Exo. g, h MTT and migration assay analysis to determine cell proliferation and migration in QBC939 cells treated with miR-34c inhibitor and/or WNT1 siRNA; Scale bar, 50 µm. *P < 0.05, **P < 0.01 vs. inhibitor NC + si-Ctrl groups; ##P < 0.01 vs. si-Ctrl + miR-34c inhibitor NC groups or inhibitor NC+si-WNT1

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Cancer Cell International

ISSN: 1475-2867

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