Fig. 8

Activated fibroblasts promote cholangiocarcinoma progression via miR-34c. Xenograft tumorigenicity assay for nude mice injected with QBC939 cells pretreated with exosomes from CCC-HSF-1 cells incubated with or without miR-34c mimics. Representative tumors (upper panel) and measurement of tumor volume and weight (lower panel) are shown. **P < 0.01 vs. NCC-Exo; ##P < 0.01 vs. NC-Exo groups